DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. [electronic resource]
Producer: 20150707Description: 1376-81 p. digitalISSN:- 1095-9203
- Adaptor Proteins, Signal Transducing
- Animals
- Azepines -- chemistry
- Cell Cycle Proteins
- Cell Line, Tumor
- Crystallography, X-Ray
- Disease Models, Animal
- Drug Design
- Leukemia, Promyelocytic, Acute -- drug therapy
- Ligands
- Mice
- Molecular Targeted Therapy
- Nuclear Proteins -- antagonists & inhibitors
- Peptide Hydrolases -- metabolism
- Phthalimides -- chemistry
- Protein Stability -- drug effects
- Protein Structure, Tertiary
- Proteolysis -- drug effects
- Tacrolimus Binding Protein 1A -- metabolism
- Thalidomide -- analogs & derivatives
- Transcription Factors -- antagonists & inhibitors
- Ubiquitin-Protein Ligases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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