DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation.
Winter, Georg E
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. [electronic resource] - Science (New York, N.Y.) Jun 2015 - 1376-81 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1095-9203
10.1126/science.aab1433 doi
Adaptor Proteins, Signal Transducing
Animals
Azepines--chemistry
Cell Cycle Proteins
Cell Line, Tumor
Crystallography, X-Ray
Disease Models, Animal
Drug Design
Leukemia, Promyelocytic, Acute--drug therapy
Ligands
Mice
Molecular Targeted Therapy
Nuclear Proteins--antagonists & inhibitors
Peptide Hydrolases--metabolism
Phthalimides--chemistry
Protein Stability--drug effects
Protein Structure, Tertiary
Proteolysis--drug effects
Tacrolimus Binding Protein 1A--metabolism
Thalidomide--analogs & derivatives
Transcription Factors--antagonists & inhibitors
Ubiquitin-Protein Ligases--metabolism
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. [electronic resource] - Science (New York, N.Y.) Jun 2015 - 1376-81 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1095-9203
10.1126/science.aab1433 doi
Adaptor Proteins, Signal Transducing
Animals
Azepines--chemistry
Cell Cycle Proteins
Cell Line, Tumor
Crystallography, X-Ray
Disease Models, Animal
Drug Design
Leukemia, Promyelocytic, Acute--drug therapy
Ligands
Mice
Molecular Targeted Therapy
Nuclear Proteins--antagonists & inhibitors
Peptide Hydrolases--metabolism
Phthalimides--chemistry
Protein Stability--drug effects
Protein Structure, Tertiary
Proteolysis--drug effects
Tacrolimus Binding Protein 1A--metabolism
Thalidomide--analogs & derivatives
Transcription Factors--antagonists & inhibitors
Ubiquitin-Protein Ligases--metabolism