Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis. [electronic resource]
Producer: 20160524Description: 18038-49 p. digitalISSN:- 1949-2553
- Adaptor Proteins, Signal Transducing -- metabolism
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Caspases -- metabolism
- Cell Cycle Proteins
- Cell Line, Tumor
- Cell Movement -- drug effects
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- G1 Phase Cell Cycle Checkpoints -- drug effects
- High-Throughput Screening Assays
- Humans
- Inhibitor of Apoptosis Proteins -- metabolism
- Mice, Inbred NOD
- Molecular Targeted Therapy
- Naphthyridines -- pharmacology
- Neoplasm Invasiveness
- Phosphoproteins -- metabolism
- Phosphorylation
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-akt -- metabolism
- Ribosomal Protein S6 Kinases, 70-kDa -- metabolism
- Signal Transduction -- drug effects
- Survivin
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Thyroid Carcinoma, Anaplastic -- drug therapy
- Thyroid Neoplasms -- drug therapy
- Time Factors
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Intramural
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