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Sadowski, Samira M

Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis. [electronic resource] - Oncotarget Jul 2015 - 18038-49 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Intramural

ISSN: 1949-2553

Standard No.: 10.18632/oncotarget.3833 doi

Subjects--Topical Terms:
Adaptor Proteins, Signal Transducing--metabolism
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Caspases--metabolism
Cell Cycle Proteins
Cell Line, Tumor
Cell Movement--drug effects
Cell Proliferation--drug effects
Dose-Response Relationship, Drug
G1 Phase Cell Cycle Checkpoints--drug effects
High-Throughput Screening Assays
Humans
Inhibitor of Apoptosis Proteins--metabolism
Mice, Inbred NOD
Molecular Targeted Therapy
Naphthyridines--pharmacology
Neoplasm Invasiveness
Phosphoproteins--metabolism
Phosphorylation
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-akt--metabolism
Ribosomal Protein S6 Kinases, 70-kDa--metabolism
Signal Transduction--drug effects
Survivin
TOR Serine-Threonine Kinases--antagonists & inhibitors
Thyroid Carcinoma, Anaplastic--drug therapy
Thyroid Neoplasms--drug therapy
Time Factors
Xenograft Model Antitumor Assays