The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway. [electronic resource]
Producer: 20160620Description: 415-26 p. digitalISSN:- 1476-5594
- Animals
- Caenorhabditis elegans -- cytology
- Caenorhabditis elegans Proteins
- Cell Line -- drug effects
- Cell Nucleolus -- drug effects
- Cyclopentanes -- pharmacology
- Genes, p53 -- drug effects
- Humans
- MCF-7 Cells -- drug effects
- Metabolic Networks and Pathways -- drug effects
- Mice, Mutant Strains
- NEDD8 Protein
- Proto-Oncogene Proteins c-mdm2 -- genetics
- Pyrimidines -- pharmacology
- Ribosomal Proteins -- genetics
- Ribosomes -- drug effects
- Ubiquitins -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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