The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway.

Bailly, A

The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway. [electronic resource] - Oncogene Jan 2016 - 415-26 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1476-5594

10.1038/onc.2015.104 doi


Animals
Caenorhabditis elegans--cytology
Caenorhabditis elegans Proteins
Cell Line--drug effects
Cell Nucleolus--drug effects
Cyclopentanes--pharmacology
Genes, p53--drug effects
Humans
MCF-7 Cells--drug effects
Metabolic Networks and Pathways--drug effects
Mice, Mutant Strains
NEDD8 Protein
Proto-Oncogene Proteins c-mdm2--genetics
Pyrimidines--pharmacology
Ribosomal Proteins--genetics
Ribosomes--drug effects
Ubiquitins--antagonists & inhibitors