Roundabout4 suppresses glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated PI3K/AKT and FAK signaling pathways. [electronic resource]
Producer: 20151228Description: 1689-705 p. digitalISSN:- 1421-9778
- Cell Line
- Cell Movement -- drug effects
- Cell Proliferation -- drug effects
- Chromones -- pharmacology
- Cinnamates -- pharmacology
- Culture Media, Conditioned -- pharmacology
- Endothelial Cells -- cytology
- Focal Adhesion Kinase 1 -- antagonists & inhibitors
- Glioma -- metabolism
- Humans
- Intercellular Signaling Peptides and Proteins -- genetics
- Morpholines -- pharmacology
- Neovascularization, Physiologic -- drug effects
- Nerve Tissue Proteins -- genetics
- Phosphatidylinositol 3-Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- RNA Interference
- Receptors, Cell Surface -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Vascular Endothelial Growth Factor A -- pharmacology
- Vascular Endothelial Growth Factor Receptor-2 -- antagonists & inhibitors
- Slit Homolog 2 Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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