Roundabout4 suppresses glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated PI3K/AKT and FAK signaling pathways.

Cai, Heng

Roundabout4 suppresses glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated PI3K/AKT and FAK signaling pathways. [electronic resource] - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015 - 1689-705 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1421-9778

10.1159/000373982 doi


Cell Line
Cell Movement--drug effects
Cell Proliferation--drug effects
Chromones--pharmacology
Cinnamates--pharmacology
Culture Media, Conditioned--pharmacology
Endothelial Cells--cytology
Focal Adhesion Kinase 1--antagonists & inhibitors
Glioma--metabolism
Humans
Intercellular Signaling Peptides and Proteins--genetics
Morpholines--pharmacology
Neovascularization, Physiologic--drug effects
Nerve Tissue Proteins--genetics
Phosphatidylinositol 3-Kinases--metabolism
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
RNA Interference
Receptors, Cell Surface--antagonists & inhibitors
Signal Transduction--drug effects
Vascular Endothelial Growth Factor A--pharmacology
Vascular Endothelial Growth Factor Receptor-2--antagonists & inhibitors
Slit Homolog 2 Protein