A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C). [electronic resource]
Producer: 20160218Description: e0121072 p. digitalISSN:- 1932-6203
- Animals
- Disease Models, Animal
- Dopamine -- biosynthesis
- Dopaminergic Neurons -- metabolism
- Gene Expression
- Imidazoles -- administration & dosage
- Inflammation -- chemically induced
- Male
- Microglia -- metabolism
- Nerve Degeneration -- drug therapy
- Neuroprotection -- drug effects
- Nuclear Receptor Subfamily 4, Group A, Member 2 -- agonists
- Oxidopamine -- toxicity
- Parkinson Disease, Secondary -- drug therapy
- Pars Compacta -- drug effects
- Poly I-C -- administration & dosage
- Pyridines -- administration & dosage
- RNA, Double-Stranded
- Rats
- Toll-Like Receptor 3 -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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