A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).
Smith, Gaynor A
A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C). [electronic resource] - PloS one 2015 - e0121072 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0121072 doi
Animals
Disease Models, Animal
Dopamine--biosynthesis
Dopaminergic Neurons--metabolism
Gene Expression
Imidazoles--administration & dosage
Inflammation--chemically induced
Male
Microglia--metabolism
Nerve Degeneration--drug therapy
Neuroprotection--drug effects
Nuclear Receptor Subfamily 4, Group A, Member 2--agonists
Oxidopamine--toxicity
Parkinson Disease, Secondary--drug therapy
Pars Compacta--drug effects
Poly I-C--administration & dosage
Pyridines--administration & dosage
RNA, Double-Stranded
Rats
Toll-Like Receptor 3--biosynthesis
A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C). [electronic resource] - PloS one 2015 - e0121072 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0121072 doi
Animals
Disease Models, Animal
Dopamine--biosynthesis
Dopaminergic Neurons--metabolism
Gene Expression
Imidazoles--administration & dosage
Inflammation--chemically induced
Male
Microglia--metabolism
Nerve Degeneration--drug therapy
Neuroprotection--drug effects
Nuclear Receptor Subfamily 4, Group A, Member 2--agonists
Oxidopamine--toxicity
Parkinson Disease, Secondary--drug therapy
Pars Compacta--drug effects
Poly I-C--administration & dosage
Pyridines--administration & dosage
RNA, Double-Stranded
Rats
Toll-Like Receptor 3--biosynthesis