Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5. [electronic resource]
Producer: 20150803Description: 210-22 p. digitalISSN:- 1096-0341
- Amino Acid Sequence
- Brain -- metabolism
- Computational Biology
- HIV Envelope Protein gp120 -- chemistry
- HIV Infections -- genetics
- HIV-1 -- chemistry
- Humans
- Macrophages -- metabolism
- Molecular Sequence Data
- Polymorphism, Single Nucleotide
- Protein Binding
- Protein Structure, Secondary
- Receptors, CCR5 -- genetics
- Sequence Alignment
- Viral Tropism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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