Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5.

Mefford, Megan E

Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5. [electronic resource] - Virology Jul 2015 - 210-22 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1096-0341

10.1016/j.virol.2015.01.032 doi


Amino Acid Sequence
Brain--metabolism
Computational Biology
HIV Envelope Protein gp120--chemistry
HIV Infections--genetics
HIV-1--chemistry
Humans
Macrophages--metabolism
Molecular Sequence Data
Polymorphism, Single Nucleotide
Protein Binding
Protein Structure, Secondary
Receptors, CCR5--genetics
Sequence Alignment
Viral Tropism