The NADPH oxidase inhibitor DPI can abolish hypoxia-induced apoptosis of human kidney proximal tubular epithelial cells through Bcl2 up-regulation via ERK activation without ROS reduction. [electronic resource]
Producer: 20150511Description: 69-75 p. digitalISSN:- 1879-0631
- Antimutagenic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Hypoxia -- drug effects
- Cell Line
- Cell Survival -- drug effects
- Cobalt -- pharmacology
- Enzyme Activation -- drug effects
- Epithelial Cells -- metabolism
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Humans
- Kidney Tubules, Proximal -- metabolism
- MAP Kinase Signaling System -- drug effects
- NADPH Oxidases -- antagonists & inhibitors
- Onium Compounds -- pharmacology
- Proto-Oncogene Proteins c-bcl-2 -- biosynthesis
- Reactive Oxygen Species -- metabolism
- Reperfusion Injury -- metabolism
- Up-Regulation -- drug effects
- bcl-2-Associated X Protein -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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