The NADPH oxidase inhibitor DPI can abolish hypoxia-induced apoptosis of human kidney proximal tubular epithelial cells through Bcl2 up-regulation via ERK activation without ROS reduction.

Song, Hyunkeun

The NADPH oxidase inhibitor DPI can abolish hypoxia-induced apoptosis of human kidney proximal tubular epithelial cells through Bcl2 up-regulation via ERK activation without ROS reduction. [electronic resource] - Life sciences Apr 2015 - 69-75 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1879-0631

10.1016/j.lfs.2015.02.004 doi


Antimutagenic Agents--pharmacology
Apoptosis--drug effects
Cell Hypoxia--drug effects
Cell Line
Cell Survival--drug effects
Cobalt--pharmacology
Enzyme Activation--drug effects
Epithelial Cells--metabolism
Extracellular Signal-Regulated MAP Kinases--metabolism
Humans
Kidney Tubules, Proximal--metabolism
MAP Kinase Signaling System--drug effects
NADPH Oxidases--antagonists & inhibitors
Onium Compounds--pharmacology
Proto-Oncogene Proteins c-bcl-2--biosynthesis
Reactive Oxygen Species--metabolism
Reperfusion Injury--metabolism
Up-Regulation--drug effects
bcl-2-Associated X Protein--biosynthesis