IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction. [electronic resource]
Producer: 20150519Description: 354-65 p. digitalISSN:- 1529-2916
- Animals
- Cell Line
- Gene Expression Regulation
- Humans
- Immunity, Innate
- Inflammation -- genetics
- Interleukin-1 -- genetics
- Interleukin-18 Receptor alpha Subunit -- antagonists & inhibitors
- Leukocytes, Mononuclear -- drug effects
- Lipopolysaccharides -- pharmacology
- MAP Kinase Kinase Kinases -- genetics
- Mice
- Mice, Transgenic
- NF-kappa B -- genetics
- PTEN Phosphohydrolase -- genetics
- Protein Binding
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins c-fyn -- genetics
- RNA, Small Interfering -- genetics
- RNA-Binding Proteins -- genetics
- Receptor Protein-Tyrosine Kinases -- genetics
- Receptors, Interleukin-1 -- antagonists & inhibitors
- STAT3 Transcription Factor -- genetics
- Signal Transduction -- immunology
- TOR Serine-Threonine Kinases -- genetics
- c-Mer Tyrosine Kinase
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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