IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.

Nold-Petry, Claudia A

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction. [electronic resource] - Nature immunology Apr 2015 - 354-65 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1529-2916

10.1038/ni.3103 doi


Animals
Cell Line
Gene Expression Regulation
Humans
Immunity, Innate
Inflammation--genetics
Interleukin-1--genetics
Interleukin-18 Receptor alpha Subunit--antagonists & inhibitors
Leukocytes, Mononuclear--drug effects
Lipopolysaccharides--pharmacology
MAP Kinase Kinase Kinases--genetics
Mice
Mice, Transgenic
NF-kappa B--genetics
PTEN Phosphohydrolase--genetics
Protein Binding
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins c-fyn--genetics
RNA, Small Interfering--genetics
RNA-Binding Proteins--genetics
Receptor Protein-Tyrosine Kinases--genetics
Receptors, Interleukin-1--antagonists & inhibitors
STAT3 Transcription Factor--genetics
Signal Transduction--immunology
TOR Serine-Threonine Kinases--genetics
c-Mer Tyrosine Kinase