Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice. [electronic resource]
Producer: 20150921Description: 1160-73 p. digitalISSN:- 1558-1497
- Animals
- Cells, Cultured
- Central Nervous System -- metabolism
- Cyclic AMP -- metabolism
- Cyclic Nucleotide Phosphodiesterases, Type 7 -- antagonists & inhibitors
- Disease Models, Animal
- Dopaminergic Neurons -- physiology
- Encephalitis -- genetics
- Gene Silencing
- Humans
- Immune System -- metabolism
- Lentivirus -- genetics
- Male
- Mice, Inbred C57BL
- Molecular Targeted Therapy
- Motor Activity -- genetics
- Nerve Degeneration -- genetics
- Parkinson Disease -- genetics
- RNA Interference
- RNA, Small Interfering -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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