Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.

Morales-Garcia, Jose A

Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice. [electronic resource] - Neurobiology of aging Feb 2015 - 1160-73 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1558-1497

10.1016/j.neurobiolaging.2014.10.008 doi


Animals
Cells, Cultured
Central Nervous System--metabolism
Cyclic AMP--metabolism
Cyclic Nucleotide Phosphodiesterases, Type 7--antagonists & inhibitors
Disease Models, Animal
Dopaminergic Neurons--physiology
Encephalitis--genetics
Gene Silencing
Humans
Immune System--metabolism
Lentivirus--genetics
Male
Mice, Inbred C57BL
Molecular Targeted Therapy
Motor Activity--genetics
Nerve Degeneration--genetics
Parkinson Disease--genetics
RNA Interference
RNA, Small Interfering--genetics