E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts. [electronic resource]
Producer: 20150720Description: 972-81 p. digitalISSN:- 1476-5586
- Animals
- Caco-2 Cells
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cells, Cultured
- Colorectal Neoplasms -- genetics
- Female
- Gene Expression -- drug effects
- HCT116 Cells
- HT29 Cells
- Human Umbilical Vein Endothelial Cells -- drug effects
- Humans
- Inhibitory Concentration 50
- Ki-67 Antigen -- metabolism
- Mice, Inbred Strains
- Mice, Nude
- Mutation
- Neovascularization, Pathologic -- prevention & control
- Phenylurea Compounds -- pharmacology
- Protein Kinase Inhibitors -- pharmacology
- Quinolines -- pharmacology
- Reverse Transcriptase Polymerase Chain Reaction
- Treatment Outcome
- Xenograft Model Antitumor Assays -- methods
- ras Proteins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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