E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts.
Wiegering, Armin
E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts. [electronic resource] - Neoplasia (New York, N.Y.) Nov 2014 - 972-81 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5586
10.1016/j.neo.2014.09.008 doi
Animals
Caco-2 Cells
Cell Line, Tumor
Cell Survival--drug effects
Cells, Cultured
Colorectal Neoplasms--genetics
Female
Gene Expression--drug effects
HCT116 Cells
HT29 Cells
Human Umbilical Vein Endothelial Cells--drug effects
Humans
Inhibitory Concentration 50
Ki-67 Antigen--metabolism
Mice, Inbred Strains
Mice, Nude
Mutation
Neovascularization, Pathologic--prevention & control
Phenylurea Compounds--pharmacology
Protein Kinase Inhibitors--pharmacology
Quinolines--pharmacology
Reverse Transcriptase Polymerase Chain Reaction
Treatment Outcome
Xenograft Model Antitumor Assays--methods
ras Proteins--genetics
E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts. [electronic resource] - Neoplasia (New York, N.Y.) Nov 2014 - 972-81 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5586
10.1016/j.neo.2014.09.008 doi
Animals
Caco-2 Cells
Cell Line, Tumor
Cell Survival--drug effects
Cells, Cultured
Colorectal Neoplasms--genetics
Female
Gene Expression--drug effects
HCT116 Cells
HT29 Cells
Human Umbilical Vein Endothelial Cells--drug effects
Humans
Inhibitory Concentration 50
Ki-67 Antigen--metabolism
Mice, Inbred Strains
Mice, Nude
Mutation
Neovascularization, Pathologic--prevention & control
Phenylurea Compounds--pharmacology
Protein Kinase Inhibitors--pharmacology
Quinolines--pharmacology
Reverse Transcriptase Polymerase Chain Reaction
Treatment Outcome
Xenograft Model Antitumor Assays--methods
ras Proteins--genetics