Inhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells. [electronic resource]
Producer: 20160226Description: 101-12 p. digitalISSN:- 1550-6606
- Active Transport, Cell Nucleus
- Adult
- Aged
- Aged, 80 and over
- Apoptosis -- drug effects
- Base Sequence
- Cell Proliferation -- drug effects
- Cells, Cultured
- Cyclic AMP -- metabolism
- Cyclic Nucleotide Phosphodiesterases, Type 4 -- metabolism
- Deoxyribonucleases -- pharmacology
- Female
- Humans
- Interferon Regulatory Factors -- metabolism
- Interferon-alpha -- biosynthesis
- Interleukin-10 -- biosynthesis
- Interleukin-6 -- biosynthesis
- Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy
- Lipopolysaccharide Receptors -- metabolism
- Male
- Middle Aged
- Monocytes -- immunology
- Phosphodiesterase 4 Inhibitors -- therapeutic use
- Rolipram -- pharmacology
- Sequence Analysis, DNA
- Signal Transduction
- Toll-Like Receptor 7 -- antagonists & inhibitors
- Toll-Like Receptor 8 -- antagonists & inhibitors
- Toll-Like Receptor 9 -- antagonists & inhibitors
- Transcription Factor RelA -- antagonists & inhibitors
- Tumor Necrosis Factor-alpha -- biosynthesis
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Publication Type: Journal Article
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