Inhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells.

Tan, Ying

Inhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Jan 2015 - 101-12 p. digital

Publication Type: Journal Article

1550-6606

10.4049/jimmunol.1401854 doi


Active Transport, Cell Nucleus
Adult
Aged
Aged, 80 and over
Apoptosis--drug effects
Base Sequence
Cell Proliferation--drug effects
Cells, Cultured
Cyclic AMP--metabolism
Cyclic Nucleotide Phosphodiesterases, Type 4--metabolism
Deoxyribonucleases--pharmacology
Female
Humans
Interferon Regulatory Factors--metabolism
Interferon-alpha--biosynthesis
Interleukin-10--biosynthesis
Interleukin-6--biosynthesis
Leukemia, Lymphocytic, Chronic, B-Cell--drug therapy
Lipopolysaccharide Receptors--metabolism
Male
Middle Aged
Monocytes--immunology
Phosphodiesterase 4 Inhibitors--therapeutic use
Rolipram--pharmacology
Sequence Analysis, DNA
Signal Transduction
Toll-Like Receptor 7--antagonists & inhibitors
Toll-Like Receptor 8--antagonists & inhibitors
Toll-Like Receptor 9--antagonists & inhibitors
Transcription Factor RelA--antagonists & inhibitors
Tumor Necrosis Factor-alpha--biosynthesis