Comparison of the circulating metabolite profile of PF-04991532, a hepatoselective glucokinase activator, across preclinical species and humans: potential implications in metabolites in safety testing assessment. [electronic resource]
Producer: 20151124Description: 190-8 p. digitalISSN:- 1521-009X
- Aged
- Animals
- Animals, Inbred Strains
- Biotransformation
- Carbon Radioisotopes
- Dogs
- Drug Evaluation, Preclinical
- Enzyme Activators -- analysis
- Feces -- chemistry
- Female
- Glucokinase -- chemistry
- Half-Life
- Humans
- Hypoglycemic Agents -- analysis
- Imidazoles -- analysis
- Liver -- drug effects
- Male
- Middle Aged
- Molecular Structure
- Nicotinic Acids -- analysis
- Organ Specificity
- Rats, Sprague-Dawley
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Publication Type: Clinical Trial, Phase I; Comparative Study; Journal Article
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