Comparison of the circulating metabolite profile of PF-04991532, a hepatoselective glucokinase activator, across preclinical species and humans: potential implications in metabolites in safety testing assessment.

Sharma, Raman

Comparison of the circulating metabolite profile of PF-04991532, a hepatoselective glucokinase activator, across preclinical species and humans: potential implications in metabolites in safety testing assessment. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Feb 2015 - 190-8 p. digital

Publication Type: Clinical Trial, Phase I; Comparative Study; Journal Article

1521-009X

10.1124/dmd.114.061218 doi


Aged
Animals
Animals, Inbred Strains
Biotransformation
Carbon Radioisotopes
Dogs
Drug Evaluation, Preclinical
Enzyme Activators--analysis
Feces--chemistry
Female
Glucokinase--chemistry
Half-Life
Humans
Hypoglycemic Agents--analysis
Imidazoles--analysis
Liver--drug effects
Male
Middle Aged
Molecular Structure
Nicotinic Acids--analysis
Organ Specificity
Rats, Sprague-Dawley