Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia. [electronic resource]
Producer: 20150604Description: 981-4 p. digitalISSN:- 1476-5551
- Antineoplastic Agents -- pharmacology
- B-Lymphocytes -- drug effects
- Bendamustine Hydrochloride
- Biphenyl Compounds -- pharmacology
- Bridged Bicyclo Compounds, Heterocyclic -- pharmacology
- CD40 Ligand -- genetics
- Cell Hypoxia
- Cells, Cultured
- Drug Resistance, Neoplasm
- Enzyme Activation
- Gene Expression Regulation, Leukemic
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell -- genetics
- Myeloid Cell Leukemia Sequence 1 Protein -- antagonists & inhibitors
- Nitrogen Mustard Compounds -- pharmacology
- Nitrophenols -- pharmacology
- Oxygen -- pharmacology
- Piperazines -- pharmacology
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Signal Transduction
- Sulfonamides -- pharmacology
- Vidarabine -- analogs & derivatives
- bcl-X Protein -- genetics
- p38 Mitogen-Activated Protein Kinases -- genetics
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Publication Type: Letter; Research Support, Non-U.S. Gov't
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