Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia.

Huelsemann, M F

Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia. [electronic resource] - Leukemia Apr 2015 - 981-4 p. digital

Publication Type: Letter; Research Support, Non-U.S. Gov't

1476-5551

10.1038/leu.2014.320 doi


Antineoplastic Agents--pharmacology
B-Lymphocytes--drug effects
Bendamustine Hydrochloride
Biphenyl Compounds--pharmacology
Bridged Bicyclo Compounds, Heterocyclic--pharmacology
CD40 Ligand--genetics
Cell Hypoxia
Cells, Cultured
Drug Resistance, Neoplasm
Enzyme Activation
Gene Expression Regulation, Leukemic
Humans
Leukemia, Lymphocytic, Chronic, B-Cell--genetics
Myeloid Cell Leukemia Sequence 1 Protein--antagonists & inhibitors
Nitrogen Mustard Compounds--pharmacology
Nitrophenols--pharmacology
Oxygen--pharmacology
Piperazines--pharmacology
Proto-Oncogene Proteins c-bcl-2--genetics
Signal Transduction
Sulfonamides--pharmacology
Vidarabine--analogs & derivatives
bcl-X Protein--genetics
p38 Mitogen-Activated Protein Kinases--genetics