Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance. [electronic resource]
Producer: 20150423Description: 16508-13 p. digitalISSN:- 1091-6490
- Animals
- Carnitine -- analogs & derivatives
- Citric Acid Cycle
- Dietary Fats -- pharmacology
- Enzyme Activation
- Fatty Acids -- metabolism
- Glucose -- metabolism
- Glycogen -- metabolism
- Hyperinsulinism -- metabolism
- Insulin Resistance -- physiology
- Isoenzymes -- metabolism
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Models, Biological
- Muscle, Skeletal -- metabolism
- Nuclear Magnetic Resonance, Biomolecular
- Oxidation-Reduction
- Oxidative Stress
- Phosphorylation
- Protein Kinase C -- metabolism
- Protein Kinase C-theta
- Protein Processing, Post-Translational
- Protein Serine-Threonine Kinases -- deficiency
- Pyruvate Dehydrogenase Acetyl-Transferring Kinase
- Pyruvate Dehydrogenase Complex -- genetics
- RNA, Messenger -- biosynthesis
- Reactive Oxygen Species -- metabolism
- Substrate Specificity
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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