Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance.
Rahimi, Yasmeen
Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Nov 2014 - 16508-13 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1419104111 doi
Animals
Carnitine--analogs & derivatives
Citric Acid Cycle
Dietary Fats--pharmacology
Enzyme Activation
Fatty Acids--metabolism
Glucose--metabolism
Glycogen--metabolism
Hyperinsulinism--metabolism
Insulin Resistance--physiology
Isoenzymes--metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Models, Biological
Muscle, Skeletal--metabolism
Nuclear Magnetic Resonance, Biomolecular
Oxidation-Reduction
Oxidative Stress
Phosphorylation
Protein Kinase C--metabolism
Protein Kinase C-theta
Protein Processing, Post-Translational
Protein Serine-Threonine Kinases--deficiency
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
Pyruvate Dehydrogenase Complex--genetics
RNA, Messenger--biosynthesis
Reactive Oxygen Species--metabolism
Substrate Specificity
Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Nov 2014 - 16508-13 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1419104111 doi
Animals
Carnitine--analogs & derivatives
Citric Acid Cycle
Dietary Fats--pharmacology
Enzyme Activation
Fatty Acids--metabolism
Glucose--metabolism
Glycogen--metabolism
Hyperinsulinism--metabolism
Insulin Resistance--physiology
Isoenzymes--metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Models, Biological
Muscle, Skeletal--metabolism
Nuclear Magnetic Resonance, Biomolecular
Oxidation-Reduction
Oxidative Stress
Phosphorylation
Protein Kinase C--metabolism
Protein Kinase C-theta
Protein Processing, Post-Translational
Protein Serine-Threonine Kinases--deficiency
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
Pyruvate Dehydrogenase Complex--genetics
RNA, Messenger--biosynthesis
Reactive Oxygen Species--metabolism
Substrate Specificity