Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase. [electronic resource]
Producer: 20150223Description: 71-8 p. digitalISSN:- 1524-4636
- Angiotensin II -- metabolism
- Animals
- Binding Sites
- CCCTC-Binding Factor
- Cells, Cultured
- Cellular Senescence -- drug effects
- Cyclin-Dependent Kinase Inhibitor p16 -- metabolism
- Cyclin-Dependent Kinase Inhibitor p21 -- metabolism
- DNA Methylation -- drug effects
- Disease Models, Animal
- Folic Acid -- pharmacology
- Gene Expression Regulation, Enzymologic
- Homocysteine -- pharmacology
- Human Umbilical Vein Endothelial Cells -- drug effects
- Humans
- Hyperhomocysteinemia -- blood
- Male
- Mice, Inbred C57BL
- Promoter Regions, Genetic
- RNA Interference
- Repressor Proteins -- genetics
- S-Adenosylmethionine -- pharmacology
- Sp1 Transcription Factor -- genetics
- Telomerase -- genetics
- Telomere -- drug effects
- Telomere Shortening -- drug effects
- Time Factors
- Transfection
- Tumor Suppressor Protein p53 -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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