Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase.

Zhang, Donghong

Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase. [electronic resource] - Arteriosclerosis, thrombosis, and vascular biology Jan 2015 - 71-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1524-4636

10.1161/ATVBAHA.114.303899 doi


Angiotensin II--metabolism
Animals
Binding Sites
CCCTC-Binding Factor
Cells, Cultured
Cellular Senescence--drug effects
Cyclin-Dependent Kinase Inhibitor p16--metabolism
Cyclin-Dependent Kinase Inhibitor p21--metabolism
DNA Methylation--drug effects
Disease Models, Animal
Folic Acid--pharmacology
Gene Expression Regulation, Enzymologic
Homocysteine--pharmacology
Human Umbilical Vein Endothelial Cells--drug effects
Humans
Hyperhomocysteinemia--blood
Male
Mice, Inbred C57BL
Promoter Regions, Genetic
RNA Interference
Repressor Proteins--genetics
S-Adenosylmethionine--pharmacology
Sp1 Transcription Factor--genetics
Telomerase--genetics
Telomere--drug effects
Telomere Shortening--drug effects
Time Factors
Transfection
Tumor Suppressor Protein p53--metabolism