5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts. [electronic resource]
Producer: 20151217Description: e107890 p. digitalISSN:- 1932-6203
- Animals
- Arachidonate 5-Lipoxygenase -- deficiency
- Chemokine CCL2 -- blood
- Edema -- drug therapy
- Enzyme Activation -- drug effects
- Fibroblasts -- drug effects
- Gene Knockout Techniques
- Humans
- I-kappa B Kinase -- metabolism
- Inflammation -- chemically induced
- Interleukin-6 -- genetics
- Leukotriene B4 -- metabolism
- Lipoxygenase Inhibitors -- pharmacology
- Male
- Mice
- Mice, Inbred C57BL
- Phosphorylation -- drug effects
- Proteolysis -- drug effects
- RNA Interference
- RNA, Small Interfering -- genetics
- Synovial Membrane -- pathology
- Tumor Necrosis Factor-alpha -- adverse effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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