5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts.

Lin, Han-Ching

5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts. [electronic resource] - PloS one 2014 - e107890 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0107890 doi


Animals
Arachidonate 5-Lipoxygenase--deficiency
Chemokine CCL2--blood
Edema--drug therapy
Enzyme Activation--drug effects
Fibroblasts--drug effects
Gene Knockout Techniques
Humans
I-kappa B Kinase--metabolism
Inflammation--chemically induced
Interleukin-6--genetics
Leukotriene B4--metabolism
Lipoxygenase Inhibitors--pharmacology
Male
Mice
Mice, Inbred C57BL
Phosphorylation--drug effects
Proteolysis--drug effects
RNA Interference
RNA, Small Interfering--genetics
Synovial Membrane--pathology
Tumor Necrosis Factor-alpha--adverse effects