The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity. [electronic resource]
Producer: 20151124Description: 125-35 p. digitalISSN:- 2326-6074
- Animals
- Antigens, CD19 -- immunology
- Burkitt Lymphoma -- immunology
- Cell Death -- immunology
- Cell Line, Tumor
- Cytotoxicity, Immunologic
- Genetic Engineering -- methods
- Genetic Vectors
- Humans
- Immunoglobulin G -- immunology
- Immunophenotyping -- methods
- Immunotherapy, Adoptive -- methods
- Lentivirus -- genetics
- Lung -- immunology
- Lymphocyte Activation -- immunology
- Mice, Inbred NOD
- Mice, SCID
- Protein Structure, Tertiary
- Receptors, Antigen, T-Cell -- immunology
- Recombinant Fusion Proteins -- immunology
- Signal Transduction -- immunology
- Structure-Activity Relationship
- T-Lymphocytes -- immunology
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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