The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity.
Hudecek, Michael
The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity. [electronic resource] - Cancer immunology research Feb 2015 - 125-35 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2326-6074
10.1158/2326-6066.CIR-14-0127 doi
Animals
Antigens, CD19--immunology
Burkitt Lymphoma--immunology
Cell Death--immunology
Cell Line, Tumor
Cytotoxicity, Immunologic
Genetic Engineering--methods
Genetic Vectors
Humans
Immunoglobulin G--immunology
Immunophenotyping--methods
Immunotherapy, Adoptive--methods
Lentivirus--genetics
Lung--immunology
Lymphocyte Activation--immunology
Mice, Inbred NOD
Mice, SCID
Protein Structure, Tertiary
Receptors, Antigen, T-Cell--immunology
Recombinant Fusion Proteins--immunology
Signal Transduction--immunology
Structure-Activity Relationship
T-Lymphocytes--immunology
Xenograft Model Antitumor Assays
The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity. [electronic resource] - Cancer immunology research Feb 2015 - 125-35 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2326-6074
10.1158/2326-6066.CIR-14-0127 doi
Animals
Antigens, CD19--immunology
Burkitt Lymphoma--immunology
Cell Death--immunology
Cell Line, Tumor
Cytotoxicity, Immunologic
Genetic Engineering--methods
Genetic Vectors
Humans
Immunoglobulin G--immunology
Immunophenotyping--methods
Immunotherapy, Adoptive--methods
Lentivirus--genetics
Lung--immunology
Lymphocyte Activation--immunology
Mice, Inbred NOD
Mice, SCID
Protein Structure, Tertiary
Receptors, Antigen, T-Cell--immunology
Recombinant Fusion Proteins--immunology
Signal Transduction--immunology
Structure-Activity Relationship
T-Lymphocytes--immunology
Xenograft Model Antitumor Assays