PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis. [electronic resource]
Producer: 20151029Description: 4573 p. digitalISSN:- 2041-1723
- Animals
- Bile Acids and Salts -- metabolism
- Cholesterol 7-alpha-Hydroxylase -- genetics
- Colon -- metabolism
- Dextran Sulfate
- Disease Models, Animal
- Feedback, Physiological
- Fibroblast Growth Factors -- genetics
- Gene Expression Regulation
- Glucuronosyltransferase -- genetics
- Homeostasis
- Inflammatory Bowel Diseases -- chemically induced
- Intestine, Small -- metabolism
- Liver -- metabolism
- Male
- Mice
- Mice, Inbred C57BL
- PPAR alpha -- antagonists & inhibitors
- RNA, Small Interfering -- genetics
- Receptors, Cytoplasmic and Nuclear -- genetics
- Signal Transduction
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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