PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis.
Zhou, Xueyan
PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis. [electronic resource] - Nature communications Sep 2014 - 4573 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2041-1723
10.1038/ncomms5573 doi
Animals
Bile Acids and Salts--metabolism
Cholesterol 7-alpha-Hydroxylase--genetics
Colon--metabolism
Dextran Sulfate
Disease Models, Animal
Feedback, Physiological
Fibroblast Growth Factors--genetics
Gene Expression Regulation
Glucuronosyltransferase--genetics
Homeostasis
Inflammatory Bowel Diseases--chemically induced
Intestine, Small--metabolism
Liver--metabolism
Male
Mice
Mice, Inbred C57BL
PPAR alpha--antagonists & inhibitors
RNA, Small Interfering--genetics
Receptors, Cytoplasmic and Nuclear--genetics
Signal Transduction
PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis. [electronic resource] - Nature communications Sep 2014 - 4573 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2041-1723
10.1038/ncomms5573 doi
Animals
Bile Acids and Salts--metabolism
Cholesterol 7-alpha-Hydroxylase--genetics
Colon--metabolism
Dextran Sulfate
Disease Models, Animal
Feedback, Physiological
Fibroblast Growth Factors--genetics
Gene Expression Regulation
Glucuronosyltransferase--genetics
Homeostasis
Inflammatory Bowel Diseases--chemically induced
Intestine, Small--metabolism
Liver--metabolism
Male
Mice
Mice, Inbred C57BL
PPAR alpha--antagonists & inhibitors
RNA, Small Interfering--genetics
Receptors, Cytoplasmic and Nuclear--genetics
Signal Transduction