Drugging MYCN through an allosteric transition in Aurora kinase A. [electronic resource]
Producer: 20141111Description: 414-427 p. digitalISSN:- 1878-3686
- Allosteric Regulation
- Animals
- Antineoplastic Agents -- chemistry
- Area Under Curve
- Aurora Kinase A -- antagonists & inhibitors
- Catalytic Domain
- Cell Line, Tumor
- Cell Survival -- drug effects
- Crystallography, X-Ray
- Humans
- Mice
- Mice, Inbred NOD
- Mice, Nude
- Mice, SCID
- Models, Molecular
- N-Myc Proto-Oncogene Protein
- Neuroblastoma -- drug therapy
- Nuclear Proteins -- chemistry
- Oncogene Proteins -- chemistry
- Phenylurea Compounds -- chemistry
- Phosphorylation
- Protein Processing, Post-Translational
- Protein Structure, Secondary
- Proteolysis
- Pyrimidines -- chemistry
- S Phase Cell Cycle Checkpoints -- drug effects
- Structure-Activity Relationship
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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