Drugging MYCN through an allosteric transition in Aurora kinase A.
Gustafson, William Clay
Drugging MYCN through an allosteric transition in Aurora kinase A. [electronic resource] - Cancer cell Sep 2014 - 414-427 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1878-3686
10.1016/j.ccr.2014.07.015 doi
Allosteric Regulation
Animals
Antineoplastic Agents--chemistry
Area Under Curve
Aurora Kinase A--antagonists & inhibitors
Catalytic Domain
Cell Line, Tumor
Cell Survival--drug effects
Crystallography, X-Ray
Humans
Mice
Mice, Inbred NOD
Mice, Nude
Mice, SCID
Models, Molecular
N-Myc Proto-Oncogene Protein
Neuroblastoma--drug therapy
Nuclear Proteins--chemistry
Oncogene Proteins--chemistry
Phenylurea Compounds--chemistry
Phosphorylation
Protein Processing, Post-Translational
Protein Structure, Secondary
Proteolysis
Pyrimidines--chemistry
S Phase Cell Cycle Checkpoints--drug effects
Structure-Activity Relationship
Tumor Burden--drug effects
Xenograft Model Antitumor Assays
Drugging MYCN through an allosteric transition in Aurora kinase A. [electronic resource] - Cancer cell Sep 2014 - 414-427 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1878-3686
10.1016/j.ccr.2014.07.015 doi
Allosteric Regulation
Animals
Antineoplastic Agents--chemistry
Area Under Curve
Aurora Kinase A--antagonists & inhibitors
Catalytic Domain
Cell Line, Tumor
Cell Survival--drug effects
Crystallography, X-Ray
Humans
Mice
Mice, Inbred NOD
Mice, Nude
Mice, SCID
Models, Molecular
N-Myc Proto-Oncogene Protein
Neuroblastoma--drug therapy
Nuclear Proteins--chemistry
Oncogene Proteins--chemistry
Phenylurea Compounds--chemistry
Phosphorylation
Protein Processing, Post-Translational
Protein Structure, Secondary
Proteolysis
Pyrimidines--chemistry
S Phase Cell Cycle Checkpoints--drug effects
Structure-Activity Relationship
Tumor Burden--drug effects
Xenograft Model Antitumor Assays