PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade. [electronic resource]
Producer: 20150212Description: 29739-49 p. digitalISSN:- 1083-351X
- AMP-Activated Protein Kinases -- metabolism
- Aerobiosis -- drug effects
- Animals
- Carcinogenesis -- metabolism
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cyclic AMP Response Element-Binding Protein -- metabolism
- Dichloroacetic Acid -- pharmacology
- Glycolysis -- drug effects
- HEK293 Cells
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
- Isoenzymes -- metabolism
- Mechanistic Target of Rapamycin Complex 1
- Mice
- Mice, Nude
- Monomeric GTP-Binding Proteins -- metabolism
- Multiprotein Complexes -- antagonists & inhibitors
- Neuropeptides -- metabolism
- PTEN Phosphohydrolase -- metabolism
- Protein Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Pyruvate Kinase -- metabolism
- Ras Homolog Enriched in Brain Protein
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Transcription, Genetic -- drug effects
- Tuberous Sclerosis Complex 2 Protein
- Tumor Suppressor Proteins -- metabolism
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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