PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.

Liu, Zhibo

PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade. [electronic resource] - The Journal of biological chemistry Oct 2014 - 29739-49 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M114.584821 doi


AMP-Activated Protein Kinases--metabolism
Aerobiosis--drug effects
Animals
Carcinogenesis--metabolism
Cell Line, Tumor
Cell Proliferation--drug effects
Cyclic AMP Response Element-Binding Protein--metabolism
Dichloroacetic Acid--pharmacology
Glycolysis--drug effects
HEK293 Cells
Humans
Hypoxia-Inducible Factor 1, alpha Subunit--metabolism
Isoenzymes--metabolism
Mechanistic Target of Rapamycin Complex 1
Mice
Mice, Nude
Monomeric GTP-Binding Proteins--metabolism
Multiprotein Complexes--antagonists & inhibitors
Neuropeptides--metabolism
PTEN Phosphohydrolase--metabolism
Protein Kinases--metabolism
Proto-Oncogene Proteins c-akt--metabolism
Pyruvate Kinase--metabolism
Ras Homolog Enriched in Brain Protein
Signal Transduction--drug effects
TOR Serine-Threonine Kinases--antagonists & inhibitors
Transcription, Genetic--drug effects
Tuberous Sclerosis Complex 2 Protein
Tumor Suppressor Proteins--metabolism
Up-Regulation--drug effects