Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor. [electronic resource]
Producer: 20150207Description: 6458-67 p. digitalISSN:- 1520-4804
- Androgen Receptor Antagonists -- chemical synthesis
- Animals
- Antineoplastic Agents -- chemical synthesis
- Benzamides
- Binding Sites
- Cell Line, Tumor
- Cell Survival -- drug effects
- Computer Simulation
- DNA -- metabolism
- Databases, Chemical
- Drug Resistance, Neoplasm
- Humans
- Imidazoles -- chemical synthesis
- Male
- Molecular Conformation
- Molecular Docking Simulation
- Morpholines -- chemical synthesis
- Mutation
- Nitriles
- Phenylthiohydantoin -- analogs & derivatives
- Prostate-Specific Antigen -- metabolism
- Prostatic Neoplasms -- drug therapy
- Pyrvinium Compounds -- chemistry
- Rats
- Receptors, Androgen -- genetics
- Structure-Activity Relationship
- Thiazoles -- chemical synthesis
- Thiophenes -- chemical synthesis
- Transcription, Genetic
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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