Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor.
Li, Huifang
Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor. [electronic resource] - Journal of medicinal chemistry Aug 2014 - 6458-67 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1520-4804
10.1021/jm500802j doi
Androgen Receptor Antagonists--chemical synthesis
Animals
Antineoplastic Agents--chemical synthesis
Benzamides
Binding Sites
Cell Line, Tumor
Cell Survival--drug effects
Computer Simulation
DNA--metabolism
Databases, Chemical
Drug Resistance, Neoplasm
Humans
Imidazoles--chemical synthesis
Male
Molecular Conformation
Molecular Docking Simulation
Morpholines--chemical synthesis
Mutation
Nitriles
Phenylthiohydantoin--analogs & derivatives
Prostate-Specific Antigen--metabolism
Prostatic Neoplasms--drug therapy
Pyrvinium Compounds--chemistry
Rats
Receptors, Androgen--genetics
Structure-Activity Relationship
Thiazoles--chemical synthesis
Thiophenes--chemical synthesis
Transcription, Genetic
Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor. [electronic resource] - Journal of medicinal chemistry Aug 2014 - 6458-67 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
1520-4804
10.1021/jm500802j doi
Androgen Receptor Antagonists--chemical synthesis
Animals
Antineoplastic Agents--chemical synthesis
Benzamides
Binding Sites
Cell Line, Tumor
Cell Survival--drug effects
Computer Simulation
DNA--metabolism
Databases, Chemical
Drug Resistance, Neoplasm
Humans
Imidazoles--chemical synthesis
Male
Molecular Conformation
Molecular Docking Simulation
Morpholines--chemical synthesis
Mutation
Nitriles
Phenylthiohydantoin--analogs & derivatives
Prostate-Specific Antigen--metabolism
Prostatic Neoplasms--drug therapy
Pyrvinium Compounds--chemistry
Rats
Receptors, Androgen--genetics
Structure-Activity Relationship
Thiazoles--chemical synthesis
Thiophenes--chemical synthesis
Transcription, Genetic