Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity. [electronic resource]
Producer: 20150616Description: 2213-22 p. digitalISSN:- 1473-5571
- Anti-HIV Agents -- metabolism
- Cells, Cultured
- Cyclin-Dependent Kinase 2 -- metabolism
- Cyclin-Dependent Kinase 6 -- metabolism
- DNA, Viral -- analysis
- HIV-1 -- physiology
- Humans
- Leukocytes, Mononuclear -- virology
- Monomeric GTP-Binding Proteins -- antagonists & inhibitors
- Piperazines -- metabolism
- Protein Kinase Inhibitors -- metabolism
- Pyridines -- metabolism
- Real-Time Polymerase Chain Reaction
- Reverse Transcription
- SAM Domain and HD Domain-Containing Protein 1
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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