Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity.
Pauls, Eduardo
Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity. [electronic resource] - AIDS (London, England) Sep 2014 - 2213-22 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1473-5571
10.1097/QAD.0000000000000399 doi
Anti-HIV Agents--metabolism
Cells, Cultured
Cyclin-Dependent Kinase 2--metabolism
Cyclin-Dependent Kinase 6--metabolism
DNA, Viral--analysis
HIV-1--physiology
Humans
Leukocytes, Mononuclear--virology
Monomeric GTP-Binding Proteins--antagonists & inhibitors
Piperazines--metabolism
Protein Kinase Inhibitors--metabolism
Pyridines--metabolism
Real-Time Polymerase Chain Reaction
Reverse Transcription
SAM Domain and HD Domain-Containing Protein 1
Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity. [electronic resource] - AIDS (London, England) Sep 2014 - 2213-22 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1473-5571
10.1097/QAD.0000000000000399 doi
Anti-HIV Agents--metabolism
Cells, Cultured
Cyclin-Dependent Kinase 2--metabolism
Cyclin-Dependent Kinase 6--metabolism
DNA, Viral--analysis
HIV-1--physiology
Humans
Leukocytes, Mononuclear--virology
Monomeric GTP-Binding Proteins--antagonists & inhibitors
Piperazines--metabolism
Protein Kinase Inhibitors--metabolism
Pyridines--metabolism
Real-Time Polymerase Chain Reaction
Reverse Transcription
SAM Domain and HD Domain-Containing Protein 1