The volatile anesthetic isoflurane increases endothelial adenosine generation via microparticle ecto-5'-nucleotidase (CD73) release. [electronic resource]
Producer: 20151019Description: e99950 p. digitalISSN:- 1932-6203
- 5'-Nucleotidase -- antagonists & inhibitors
- Adenosine -- biosynthesis
- Adenosine Diphosphate -- analogs & derivatives
- Amides -- pharmacology
- Anesthetics, Inhalation -- pharmacology
- Animals
- Antigens, CD -- genetics
- Cadherins -- genetics
- Cell Line, Transformed
- Cell-Derived Microparticles -- metabolism
- Endothelial Cells -- cytology
- Enzyme Activation -- drug effects
- Enzyme Inhibitors -- pharmacology
- Gene Expression Regulation
- Human Umbilical Vein Endothelial Cells -- cytology
- Humans
- Inflammation -- prevention & control
- Isoflurane -- pharmacology
- Kidney Glomerulus -- cytology
- Male
- Mice
- Mice, Inbred C57BL
- Myosin-Light-Chain Phosphatase -- genetics
- Pyridines -- pharmacology
- Signal Transduction
- rho-Associated Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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