The volatile anesthetic isoflurane increases endothelial adenosine generation via microparticle ecto-5'-nucleotidase (CD73) release.

Kim, Mihwa

The volatile anesthetic isoflurane increases endothelial adenosine generation via microparticle ecto-5'-nucleotidase (CD73) release. [electronic resource] - PloS one 2014 - e99950 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0099950 doi


5'-Nucleotidase--antagonists & inhibitors
Adenosine--biosynthesis
Adenosine Diphosphate--analogs & derivatives
Amides--pharmacology
Anesthetics, Inhalation--pharmacology
Animals
Antigens, CD--genetics
Cadherins--genetics
Cell Line, Transformed
Cell-Derived Microparticles--metabolism
Endothelial Cells--cytology
Enzyme Activation--drug effects
Enzyme Inhibitors--pharmacology
Gene Expression Regulation
Human Umbilical Vein Endothelial Cells--cytology
Humans
Inflammation--prevention & control
Isoflurane--pharmacology
Kidney Glomerulus--cytology
Male
Mice
Mice, Inbred C57BL
Myosin-Light-Chain Phosphatase--genetics
Pyridines--pharmacology
Signal Transduction
rho-Associated Kinases--antagonists & inhibitors