Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression. [electronic resource]
Producer: 20150427Description: 1146-56 p. digitalISSN:- 1528-0020
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Binding Sites -- genetics
- Blotting, Western
- Cell Cycle Checkpoints -- drug effects
- Cells, Cultured
- Fetal Hemoglobin -- genetics
- GTP-Binding Protein alpha Subunits, Gi-Go -- metabolism
- Gene Expression -- drug effects
- Humans
- Hydroxyurea -- pharmacology
- JNK Mitogen-Activated Protein Kinases -- metabolism
- K562 Cells
- Monomeric GTP-Binding Proteins -- genetics
- NF-kappa B -- metabolism
- Promoter Regions, Genetic -- genetics
- Proto-Oncogene Proteins c-jun -- metabolism
- RNA Interference
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction -- drug effects
- ets-Domain Protein Elk-1 -- metabolism
- gamma-Globins -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Intramural
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