Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression.
Zhu, Jianqiong
Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression. [electronic resource] - Blood Aug 2014 - 1146-56 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural
1528-0020
10.1182/blood-2013-10-534842 doi
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Binding Sites--genetics
Blotting, Western
Cell Cycle Checkpoints--drug effects
Cells, Cultured
Fetal Hemoglobin--genetics
GTP-Binding Protein alpha Subunits, Gi-Go--metabolism
Gene Expression--drug effects
Humans
Hydroxyurea--pharmacology
JNK Mitogen-Activated Protein Kinases--metabolism
K562 Cells
Monomeric GTP-Binding Proteins--genetics
NF-kappa B--metabolism
Promoter Regions, Genetic--genetics
Proto-Oncogene Proteins c-jun--metabolism
RNA Interference
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--drug effects
ets-Domain Protein Elk-1--metabolism
gamma-Globins--genetics
Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression. [electronic resource] - Blood Aug 2014 - 1146-56 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural
1528-0020
10.1182/blood-2013-10-534842 doi
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Binding Sites--genetics
Blotting, Western
Cell Cycle Checkpoints--drug effects
Cells, Cultured
Fetal Hemoglobin--genetics
GTP-Binding Protein alpha Subunits, Gi-Go--metabolism
Gene Expression--drug effects
Humans
Hydroxyurea--pharmacology
JNK Mitogen-Activated Protein Kinases--metabolism
K562 Cells
Monomeric GTP-Binding Proteins--genetics
NF-kappa B--metabolism
Promoter Regions, Genetic--genetics
Proto-Oncogene Proteins c-jun--metabolism
RNA Interference
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--drug effects
ets-Domain Protein Elk-1--metabolism
gamma-Globins--genetics