The epigenetic regulator I-BET151 induces BIM-dependent apoptosis and cell cycle arrest of human melanoma cells. [electronic resource]
Producer: 20150217Description: 2795-2805 p. digitalISSN:- 1523-1747
- Animals
- Apoptosis
- Apoptosis Regulatory Proteins -- metabolism
- Bcl-2-Like Protein 11
- Caspases -- metabolism
- Cell Cycle Checkpoints -- drug effects
- Cell Cycle Proteins
- Cell Line
- Cell Line, Tumor
- Cell Survival
- Cyclin-Dependent Kinase Inhibitor p21 -- metabolism
- DNA Mutational Analysis
- Epigenesis, Genetic
- Female
- GTP Phosphohydrolases -- metabolism
- Gene Expression Regulation, Neoplastic
- Heterocyclic Compounds, 4 or More Rings -- chemistry
- Humans
- Melanoma -- drug therapy
- Membrane Proteins -- metabolism
- Mice
- Mice, Inbred NOD
- Monomeric GTP-Binding Proteins -- metabolism
- Neoplasm Transplantation
- Nuclear Proteins -- metabolism
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins B-raf -- metabolism
- Transcription Factors -- metabolism
- Transcriptome
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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