The epigenetic regulator I-BET151 induces BIM-dependent apoptosis and cell cycle arrest of human melanoma cells.

Gallagher, Stuart J

The epigenetic regulator I-BET151 induces BIM-dependent apoptosis and cell cycle arrest of human melanoma cells. [electronic resource] - The Journal of investigative dermatology Nov 2014 - 2795-2805 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1523-1747

10.1038/jid.2014.243 doi


Animals
Apoptosis
Apoptosis Regulatory Proteins--metabolism
Bcl-2-Like Protein 11
Caspases--metabolism
Cell Cycle Checkpoints--drug effects
Cell Cycle Proteins
Cell Line
Cell Line, Tumor
Cell Survival
Cyclin-Dependent Kinase Inhibitor p21--metabolism
DNA Mutational Analysis
Epigenesis, Genetic
Female
GTP Phosphohydrolases--metabolism
Gene Expression Regulation, Neoplastic
Heterocyclic Compounds, 4 or More Rings--chemistry
Humans
Melanoma--drug therapy
Membrane Proteins--metabolism
Mice
Mice, Inbred NOD
Monomeric GTP-Binding Proteins--metabolism
Neoplasm Transplantation
Nuclear Proteins--metabolism
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins B-raf--metabolism
Transcription Factors--metabolism
Transcriptome